Choosing methods to minimize confounding in observational studies: do the ends justify the means?
نویسندگان
چکیده
The comparison of alternative treatments has long been a primary objective of researchers engaged in clinical investigation. However, with the commitment of $1.1 billion in support of clinical research in the American Recovery and Reinvestment Act,1 followed subsequently by the creation of the Patient Centered Outcomes Research Institute (PCORI) as part of the Affordable Care Act,2 “comparative effectiveness research” has grown to become a publicly discussed national priority.
منابع مشابه
Methodological issues of confounding in analytical epidemiologic studies
Background: Confounding can be thought of as mixing the effect of exposure on the risk of disease with a third factor which distorts the measure of association such as risk ratio or odds ratio. This bias arises because of complex functional relationship of confounder with both exposure and disease (outcome). In this article, we provided a conceptual framework review of confounding issues in epi...
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عنوان ژورنال:
- Circulation. Cardiovascular quality and outcomes
دوره 4 6 شماره
صفحات -
تاریخ انتشار 2011